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ANTISTAX® active leg tablets. Dry extract of red vine leaf AS 195 (4 - 6:1) 360 mg per tablet. ANTISTAX® Double Fresh Gel contains Red Vine Leaf Extract. Western herbal. This unregistered medicine has not been evaluated by the SAHPRA for its quality, safety or intended use.

MAH: Imperial Market Access Healthcare SA (Pty) Ltd, 10 Skeen Boulevard, Bedfordview, Gauteng, 2007. Reg. no.: 2006/029994/07. General contact information: info.mahsa@imperiallogistics.com, Tel: 011 677 5000. For any quality or safety related queries, please contact Imperial Quality at quality.healthcare@imperiallogistics.com or Imperial Medical at pv@imperiallogistics.com.

References: 1. Antistax PIL 2. Antistax Double Fresh Gel PIL 3. Kiesewetter H. Koscielny J, Kalus U et al. Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II): a randomised, double-blind, placebo-controlled trial. Arzneim.-Forsch./Drug Res 2000;50(1):109-117. 4. Kalus U, Koscielny J, Grigorov A et al. Improvement of cutaneous microcirculation and oxygen supply in patients with Chronic Venous Insufficiency by orally administered extract of red vine leaves AS 195: a randomised, double-blind, placebo-controlled, crossover study. Drugs R&D 2004; 5(2): 63-71. 5. Nees S, Weiss DR, Reichenblach-Klinke E et al. Protective Effects of Flavonoids Contained in the Red Vine Leaf on Venular Endothelium against the Attack of Activated Blood Components in vitro. Arzneim.-Forsch./Drug Res. 2003;53(5):330-341. 6. https://url.avanan.click/v2/___https://my.clevelandclinic.org/health/diseases/16872-chronic-venous-insufficiency-cvi/management-and-treatment___.YXAxZTpkcHdvcmxkLXN1YnNhaGFyYWFmcmljYTphOm86ZTkwOTVlYTIyYzVhMmJhYjk3YmJjN2YzZjAyYjFlZTU6NjowYzA1OjljNzIwOGE4YTRhNjZiZjk1NTM2OTgzYjVmNWFiNGU4NWMzMGQ2NTM2MGI0NzRiNjZlNTU1M2YxZTQyMTAyNGU6dDpU (last accessed 20 February 2020) 7. Francoise Pitsch. Results of the DECIDE survey: appraisal of the predictive value for chronic venous disease of a symptom. Phlebolymphology Vol 18. No. 3. 2011 8. https://url.avanan.click/v2/___https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406103/___.YXAxZTpkcHdvcmxkLXN1YnNhaGFyYWFmcmljYTphOm86ZTkwOTVlYTIyYzVhMmJhYjk3YmJjN2YzZjAyYjFlZTU6NjozZmJhOmRiNmRjZWRjYzJmYjRlNDFiMTY3M2E5OTUwYWY2Y2U3ZmQxOTM1ZDgzZDJkYWFlYzlkNjE1Y2Y0NTQwODk2NWU6dDpU (last accessed 24 Feb 2020) 9. The Epidemiology of Chronic Venous Insufficiency and Varicose Veins by Jennifer L. Beebe-Dimmer, John R Pfeifer, Jennifer S. Engle and David Schottenfeld. March 2005 SAZA.ANTI.19.08.0315