FOR SOUTH AFRICAN RESIDENTS
Antistax® Tablets
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ANTISTAX® active leg tablets. Dry extract of red vine leaf AS 195 (4 - 6:1) 360 mg per tablet. ANTISTAX® Double Fresh Gel contains Red Vine Leaf
Extract. Western herbal. This unregistered medicine has not been evaluated by the SAHPRA for its quality, safety or intended use. Applicant:
sanofi-aventis south africa (pty) ltd, Reg. no.:1996/010381/07. Sanofi House, 2 Bond Street, Grand Central Ext. 1, Midrand, 1685. Tel: (011) 256 3700
Fax: (011) 256 3707. www.sanofi-aventis.com.
References: 1. Antistax PIL 2. Antistax Double Fresh Gel PIL 3. Kiesewetter H. Koscielny J, Kalus U et al. Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II): a randomised, double-blind, placebo-controlled trial. Arzneim.-Forsch./Drug Res 2000;50(1):109-117. 4. Kalus U, Koscielny J, Grigorov A et al. Improvement of cutaneous microcirculation and oxygen supply in patients with Chronic Venous Insufficiency by orally administered extract of red vine leaves AS 195: a randomised, double-blind, placebo-controlled, crossover study. Drugs R&D 2004; 5(2): 63-71. 5. Nees S, Weiss DR, Reichenblach-Klinke E et al. Protective Effects of Flavonoids Contained in the Red Vine Leaf on Venular Endothelium against the Attack of Activated Blood Components in vitro. Arzneim.-Forsch./Drug Res. 2003;53(5):330-341. 6. https://my.clevelandclinic.org/health/diseases/16872-chronic-venous-insufficiency-cvi/management-and-treatment (last accessed 20 February 2020) 7. Francoise Pitsch. Results of the DECIDE survey: appraisal of the predictive value for chronic venous disease of a symptom. Phlebolymphology Vol 18. No. 3. 2011 8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406103/ (last accessed 24 Feb 2020) 9. The Epidemiology of Chronic Venous Insufficiency and Varicose Veins by Jennifer L. Beebe-Dimmer, John R Pfeifer, Jennifer S. Engle and David Schottenfeld. March 2005 SAZA.ANTI.19.08.0315
References: 1. Antistax PIL 2. Antistax Double Fresh Gel PIL 3. Kiesewetter H. Koscielny J, Kalus U et al. Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II): a randomised, double-blind, placebo-controlled trial. Arzneim.-Forsch./Drug Res 2000;50(1):109-117. 4. Kalus U, Koscielny J, Grigorov A et al. Improvement of cutaneous microcirculation and oxygen supply in patients with Chronic Venous Insufficiency by orally administered extract of red vine leaves AS 195: a randomised, double-blind, placebo-controlled, crossover study. Drugs R&D 2004; 5(2): 63-71. 5. Nees S, Weiss DR, Reichenblach-Klinke E et al. Protective Effects of Flavonoids Contained in the Red Vine Leaf on Venular Endothelium against the Attack of Activated Blood Components in vitro. Arzneim.-Forsch./Drug Res. 2003;53(5):330-341. 6. https://my.clevelandclinic.org/health/diseases/16872-chronic-venous-insufficiency-cvi/management-and-treatment (last accessed 20 February 2020) 7. Francoise Pitsch. Results of the DECIDE survey: appraisal of the predictive value for chronic venous disease of a symptom. Phlebolymphology Vol 18. No. 3. 2011 8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406103/ (last accessed 24 Feb 2020) 9. The Epidemiology of Chronic Venous Insufficiency and Varicose Veins by Jennifer L. Beebe-Dimmer, John R Pfeifer, Jennifer S. Engle and David Schottenfeld. March 2005 SAZA.ANTI.19.08.0315